Journal: Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring

Article Title: Factors affecting the harmonization of disease-related metabolic brain pattern expression quantification in [ 18 F]FDG-PET (PETMETPAT)

doi: 10.1016/j.dadm.2019.04.002

Figure Lengend Snippet: The effects of Gaussian FWHM smoothing filter, TOF/PSF, and matrix size on raw, absolute PDRP expression scores in the H3DBP and five HC, RBD, and PD subjects scanned on the Siemens Biograph mCT64 PET/CT system at the UMCG. In all human subjects and the H3DBP, the reconstruction combination of 10 mm Gaussian filter, TOF−/PSF−, and matrix size of 256 consistently leads to the highest raw PDRP expression score, whereas the reconstruction combination of no Gaussian filter (0 mm/“all-pass”), and with TOF+/PSF+ and matrix size of 400, consistently leads to the lowest PDRP expression score. Per definition (based on how the PDRP is defined in this case) , , HCs tend to express more-negative raw PDRP values, and patients with PD tend to express more-positive raw PDRP values. Disease expression scores tend to increase with disease advancement. Abbreviations: FWHM, Full-width at half-maximum; TOF, time of flight; PSF, point spread function; PDRP, Parkinson's disease–related pattern; H3DBP, Hoffman 3D Brain Phantom; HC, healthy control; PD, Parkinson's disease; PET, positron emission tomography; CT, computed tomography; UMCG, University Medical Center Groningen.

Article Snippet: To this end, in-house code was created with MATLAB R2017b to re-scale the image intensity of H3DBP data obtained from the GE710, Philips Vereos, and Philips Ingenuity scanners to match the intensity range of the H3DBP data obtained from the UMCG's Siemens Biograph mCT64 scanner, reconstructed with TOF+/PSF+, matrix size 256.

Techniques: Expressing, Positron Emission Tomography-Computed Tomography, Control, Positron Emission Tomography, Computed Tomography

Journal: Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring

Article Title: Factors affecting the harmonization of disease-related metabolic brain pattern expression quantification in [ 18 F]FDG-PET (PETMETPAT)

doi: 10.1016/j.dadm.2019.04.002

Figure Lengend Snippet: Median and IQR of raw PDRP expression scores in the H3DBP/HC/RBD/PD scanned on the Siemens Biograph mCT64 PET/CT system at the UMCG

Article Snippet: To this end, in-house code was created with MATLAB R2017b to re-scale the image intensity of H3DBP data obtained from the GE710, Philips Vereos, and Philips Ingenuity scanners to match the intensity range of the H3DBP data obtained from the UMCG's Siemens Biograph mCT64 scanner, reconstructed with TOF+/PSF+, matrix size 256.

Techniques: Expressing

Journal: Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring

Article Title: Factors affecting the harmonization of disease-related metabolic brain pattern expression quantification in [ 18 F]FDG-PET (PETMETPAT)

doi: 10.1016/j.dadm.2019.04.002

Figure Lengend Snippet: Normalized H3DBP scan versus normalized HC1 scan (Gaussian FWHM 8 mm filter, TOF+/PSF+, matrix 256; with approximately 50 MBq and 200 MBq [ 18 F]FDG used in the H3DBP and HC1, respectively). Both scans were obtained from the Siemens Biograph mCT64 PET/CT System at the UMCG in the Netherlands . Abbreviations: FWHM, Full-width at half-maximum; TOF, time of flight; PSF, point spread function; H3DBP, Hoffman 3D Brain Phantom; FDG, fluorodeoxyglucose; UMCG, University Medical Center Groningen.

Article Snippet: To this end, in-house code was created with MATLAB R2017b to re-scale the image intensity of H3DBP data obtained from the GE710, Philips Vereos, and Philips Ingenuity scanners to match the intensity range of the H3DBP data obtained from the UMCG's Siemens Biograph mCT64 scanner, reconstructed with TOF+/PSF+, matrix size 256.

Techniques: Positron Emission Tomography-Computed Tomography

Journal: Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring

Article Title: Factors affecting the harmonization of disease-related metabolic brain pattern expression quantification in [ 18 F]FDG-PET (PETMETPAT)

doi: 10.1016/j.dadm.2019.04.002

Figure Lengend Snippet: HC and PD gray-to-white matter ratios versus raw PDRP expression scores. Five HCs and 5 PD patients in four reconstructions each (TOF+/PSF+ with matrix size 256, TOF+/PSF+ with matrix size 400, TOF−/PSF− with matrix size 256, and TOF−/PSF− with matrix size 400) on the Siemens Biograph mCT64 at the UMCG in the Netherlands . Abbreviations: PDRP, Parkinson's disease–related pattern; TOF, time of flight; PSF, point spread function; HC, healthy control; PD, Parkinson's disease.

Article Snippet: To this end, in-house code was created with MATLAB R2017b to re-scale the image intensity of H3DBP data obtained from the GE710, Philips Vereos, and Philips Ingenuity scanners to match the intensity range of the H3DBP data obtained from the UMCG's Siemens Biograph mCT64 scanner, reconstructed with TOF+/PSF+, matrix size 256.

Techniques: Expressing, Control